Nodal antibody

Catalog No. ABIN6572072

This Rabbit Polyclonal antibody specifically detects Nodal in WB. It exhibits reactivity toward Human and Rat.

Quick Overview for Nodal antibody (ABIN6572072)

Target: Nodal (NODAL) (Nodal Homolog (NODAL))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nodal antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Nodal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human NODAL

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Nodal

Target: Nodal (NODAL) (Nodal Homolog (NODAL))

Alternative Name: NODAL

Background:

Synonyms: HTX5,MGC138230,Nodal,Nodal Growth Differentiation Factor,nodal homolog (mouse),Nodal homolog,Nodal,Mouse,Homolog,NODAL

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis.

Molecular Weight:

Observed_MW: 44kDa

Calculated_MW: 39kDa

Gene ID: 4838

UniProt: Q96S42

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance, Tube Formation, Positive Regulation of Endopeptidase Activity